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Determination of ssDNA breaks, 23 mitochondrial membrane depolarization, 24 caspase cleavage 24 and apoptotic DNA fragmentation 23 was carried out as previously described

Secondary NAD+deficiency in the inherited defect of glutamine synthetase

Studies published in Biochemical Pharmacology show that NNMT expression increases significantly with aging in skeletal muscle tissue and correlates with impaired muscle stem cell function and reduced regenerative capacity